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RESEARCH WORKSPACE

Overview Therapies2,752 Studies Translation & outcomes Mechanisms Research gaps Safety findings

Methods & citation

August 2026 datasetResearch window · 1980–2020

A project by Pebble.

PEBBLE / ATLAS

Open research access

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Research linked to primary sources.Privacy CookiesDataset: 25 August 2026

THE UNDERLYING RESEARCH

Studies

Return to the publications. Inspect the model, extracted findings and therapies linked to each study.

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Filters Injury, species

Injury model

BurnChemical/toxinCrushEndotoxin/LPSFractureHaemorrhage/shockIschaemia-reperfusionOtherRadiationSpinal cord injuryTBIWound

Species

Guinea pigHamsterMixedMouseRabbitRat

Match any within a group; all selected groups must match.

4,095 matching study records4,081 PMIDs + 14 records without a PMID

2018

PMID 30367162Rat

The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest.

Ischaemia-reperfusion1 linked therapy

2018

PMID 30367813Mouse

Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Cyclosporine-A via Suppression of Mitochondrial DNA.

Endotoxin/LPS1 linked therapy

2018

PMID 30369549Rat

Linagliptin protects rat carotid artery from balloon injury and activates the NRF2 antioxidant pathway.

Other1 linked therapy

2018

PMID 30372863Rat

Investigation of the effects of hesperidin and chrysin on renal injury induced by colistin in rats.

Chemical/toxin1 linked therapy

2018

PMID 30372902Mouse

YiQiFuMai lyophilized injection attenuates particulate matter-induced acute lung injury in mice via TLR4-mTOR-autophagy pathway.

Chemical/toxin1 linked therapy

2018

PMID 30378170Mouse

Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation.

TBI1 linked therapy

2018

PMID 30379318Rat

Beta-2 Adrenergic and Glucocorticoid Receptor Agonists Modulate Ozone-Induced Pulmonary Protein Leakage and Inflammation in Healthy and Adrenalectomized Rats.

Chemical/toxin1 linked therapy

2018

PMID 30379573Rat

Bromine inhalation mimics ischemia-reperfusion cardiomyocyte injury and calpain activation in rats.

Chemical/toxin1 linked therapy

2018

PMID 30388366Mouse

A Dual-Function Antibiotic-Transporter Conjugate Exhibits Superior Activity in Sterilizing MRSA Biofilms and Killing Persister Cells.

Wound1 linked therapy

2018

PMID 30390545Rat

MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management.

Wound1 linked therapy

2018

PMID 30391355Mouse

A new function for Prokineticin 2: Recruitment of SVZ-derived neuroblasts to the injured cortex in a mouse model of traumatic brain injury.

TBI1 linked therapy

2018

PMID 30391466Rat

Alogliptin abates memory injuries of hepatic encephalopathy induced by acute paracetamol intoxication via switching-off autophagy-related apoptosis.

Chemical/toxin1 linked therapy

2018

PMID 30391757Rat

Anti-High Mobility Group Box 1 Antibody Therapy May Prevent Cognitive Dysfunction After Traumatic Brain Injury.

TBI1 linked therapy

2018

PMID 30393833Mouse

An improvement in acute wound healing in mice by the combined application of photobiomodulation and curcumin-loaded iron particles.

Wound1 linked therapy

2018

PMID 30396385Rat

Analgesic effects of the novel alpha2delta ligand mirogabalin in a rat model of spinal cord injury.

Spinal cord injury1 linked therapy

2018

PMID 30396756Rat

Magnesium isoglycyrrhizinate alleviates liver injury in obese rats with acute necrotizing pancreatitis.

Chemical/toxin1 linked therapy

2018

PMID 30401412Rat

Niacin Pretreatment Attenuates Ischemia and Reperfusion of Pancreas-induced Acute Pancreatitis and Remote Lung Injury Through Suppressing Oxidative Stress and Inflammation and Activation of SIRT1.

Ischaemia-reperfusion1 linked therapy

2018

PMID 30409036Mouse

Early and Late Protective Effect of Bone Marrow Mononuclear Cell Transplantation on Radiation-Induced Vascular Dysfunction and Skin Lesions.

Radiation1 linked therapy

2018

PMID 30412790Rat

BML-111, a lipoxin receptor agonist, protects against acute injury via regulating the renin angiotensin-aldosterone system.

Endotoxin/LPS1 linked therapy

2018

PMID 30418008Rat

The effect of aerosolized indomethacin on lung inflammation and injury in a rat model of blunt chest trauma.

Other1 linked therapy

2018

PMID 30423366Mouse

Caffeine attenuates brain injury but increases mortality induced by high-intensity blast wave exposure.

TBI1 linked therapy

2018

PMID 30426855Mouse

Sicyos angulatus ameliorates acute liver injury by inhibiting oxidative stress via upregulation of anti-oxidant enzymes.

Chemical/toxin1 linked therapy

2018

PMID 30439349Rat

MEK/ERK/1/2 sensitive vascular changes coincide with retinal functional deficit, following transient ophthalmic artery occlusion.

Ischaemia-reperfusion1 linked therapy

2018

PMID 30443839Rat

Protective Effect of PACAP on Ischemia/Reperfusion-Induced Kidney Injury of Male and Female Rats: Gender Differences.

Ischaemia-reperfusion1 linked therapy

2018

PMID 30445981Rat

Bone marrow-derived mononuclear cell therapy can attenuate systemic inflammation in rat heatstroke.

Other1 linked therapy

2018

PMID 30458346Rat

Synergistic therapeutic effects of Vitis vinifera extract and Silymarin on experimentally induced cardiorenal injury: The pertinent role of Nrf2.

Chemical/toxin1 linked therapy

2018

PMID 30463600Mouse

Therapeutic efficiency of human amniotic epithelial stem cell-derived functional hepatocyte-like cells in mice with acute hepatic failure.

Chemical/toxin1 linked therapy

2018

PMID 30472522Rat

Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats.

Spinal cord injury1 linked therapy

2018

PMID 30474194Mouse

A murine model of acute lung injury identifies growth factors to promote tissue repair and their biomarkers.

Chemical/toxin1 linked therapy

2018

PMID 30478280Mouse

Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis.

Chemical/toxin1 linked therapy

2018

PMID 30482901Rat

Rapid and robust restoration of breathing long after spinal cord injury.

Spinal cord injury1 linked therapy

2018

PMID 30500623Rat

Apremilast ameliorates carfilzomib-induced pulmonary inflammation and vascular injuries.

Chemical/toxin1 linked therapy

2018

PMID 30502013Rat

A Comparison Between Two Collagen Nerve Conduits and Nerve Autograft: A Rat Model of Motor Nerve Regeneration.

Other1 linked therapy

2018

PMID 30503785Mouse

Regeneration After Radiation- and Immune-Mediated Tissue Injury Is Not Enhanced by Type III Interferon Signaling.

Radiation1 linked therapy

2018

PMID 30507321Mouse

Metal chaperones: a novel therapeutic strategy for brain injury?

TBI1 linked therapy

2018

PMID 30510400Rat

Notch inhibitor can attenuate apparent diffusion coefficient and improve neurological function through downregulating NOX2-ROS in severe traumatic brain injury.

TBI1 linked therapy

2018

PMID 30515205Mouse

Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein.

Chemical/toxin1 linked therapy

2018

PMID 30517956Mouse

Preventive effects of ketone ester BD-AcAc2 on central nervous system oxygen toxicity and concomitant acute lung injury.

Other1 linked therapy

2018

PMID 30519748Mouse

Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice.

Other1 linked therapy

2018

PMID 30523028Mouse

Identification of Specific miRNAs in Neutrophils of Type 2 Diabetic Mice: Overexpression of miRNA Accelerates Diabetic Wound Healing.

Wound1 linked therapy

2018

PMID 30526134Rat

Therapeutic hypothermia effectively reduces elevated extracellular ascorbate concentrations caused by acute spinal cord injury.

Spinal cord injury1 linked therapy

2018

PMID 30527883Rat

The effect of adipose-derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats.

Other1 linked therapy

2018

PMID 30530169Mouse

The mTORC1 signaling modulated by intracellular C3 activation in Paneth cells promotes intestinal epithelial regeneration during acute injury.

Other1 linked therapy

2018

PMID 30536300Mouse

LncRNA ZNF667-AS1 inhibits inflammatory response and promotes recovery of spinal cord injury via suppressing JAK-STAT pathway.

Spinal cord injury1 linked therapy

2018

PMID 30540880Rat

Mechanical Augmentation With Absorbable Alginate Sheet Enhances Healing of the Rotator Cuff.

Other1 linked therapy

2018

PMID 30541950Rat

Neuroectodermal stem cells: A remyelinating potential in acute compressed spinal cord injury in rat model.

Spinal cord injury1 linked therapy

2018

PMID 30548082Mouse

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury.

Haemorrhage/shock1 linked therapy

2018

PMID 30572121Mouse

Inhibition of early response genes prevents changes in global joint metabolomic profiles in mouse post-traumatic osteoarthritis.

Other1 linked therapy

2018

PMID 30573242Mouse

Processed eggshell membrane powder: Bioinspiration for an innovative wound healing product.

Wound1 linked therapy

2018

PMID 30576033Mouse

Plasma-based biomaterials for the treatment of cutaneous radiation injury.

Radiation1 linked therapy

1,201–1,250 of 4,095

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The full review includes 5,033 publications. This searchable index represents the itemised subset; the 1990–2010 window is partially indexed. Extraction details are retained per therapy association.