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RESEARCH WORKSPACE

Overview Therapies2,752 Studies Translation & outcomes Mechanisms Research gaps Safety findings

Methods & citation

August 2026 datasetResearch window · 1980–2020

A project by Pebble.

PEBBLE / ATLAS

Open research access

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Research linked to primary sources.Privacy CookiesDataset: 25 August 2026

THE UNDERLYING RESEARCH

Studies

Return to the publications. Inspect the model, extracted findings and therapies linked to each study.

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Filters Injury, species

Injury model

BurnChemical/toxinCrushEndotoxin/LPSFractureHaemorrhage/shockIschaemia-reperfusionOtherRadiationSpinal cord injuryTBIWound

Species

Guinea pigHamsterMixedMouseRabbitRat

Match any within a group; all selected groups must match.

4,095 matching study records4,081 PMIDs + 14 records without a PMID

2016

PMID 27861125Mouse

4-Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury.

Crush1 linked therapy

2016

PMID 27864032Rat

alpha-Adrenergic Receptor Antagonism Improves Erectile and Cavernosal Responses in Rats With Cavernous Nerve Injury and Enhances Neurogenic Responses in Human Corpus Cavernosum From Patients With Erectile Dysfunction Secondary to Radical Prostatectomy.

Crush1 linked therapy

2016

PMID 27874086Mixed

Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through alpha7nAChR-dependent JAK2-STAT3 signaling.

Crush1 linked therapy

2016

PMID 27881723Rat

Intraspinal microstimulation and diaphragm activation after cervical spinal cord injury.

Spinal cord injury1 linked therapy

2016

PMID 27889760Rat

Pamidronate Attenuates Oxidative Stress and Energetic Metabolism Changes but Worsens Functional Outcomes in Acute Doxorubicin-Induced Cardiotoxicity in Rats.

Chemical/toxin1 linked therapy

2016

PMID 27889808Rat

Pharmacodynamic evaluation of Lys, MeLeu, Nle-NKA prokinetic effects on bladder and colon activity in acute spinal cord transected and spinally intact rats.

Spinal cord injury1 linked therapy

2016

PMID 27893460Mouse

TGF-beta1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage.

Haemorrhage/shock1 linked therapy

2016

PMID 27899434Rat

Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache.

TBI1 linked therapy

2016

PMID 27904694Rat

Soluble Flt-1 improves the repair of ankle joint injury in rats.

Other1 linked therapy

2016

PMID 27907083Rat

Effects of Acute Systemic Hypoxia and Hypercapnia on Brain Damage in a Rat Model of Hypoxia-Ischemia.

Ischaemia-reperfusion1 linked therapy

2016

PMID 27908726Rat

Activation of G-protein coupled estrogen receptor 1 improves early-onset cognitive impairment via PI3K/Akt pathway in rats with traumatic brain injury.

TBI1 linked therapy

2016

PMID 27909615Rat

The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate.

Chemical/toxin1 linked therapy

2016

PMID 27911817Mouse

TNFalpha-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury.

Endotoxin/LPS1 linked therapy

2016

PMID 27912738Rat

Hepatoprotective activity of Lepidium sativum seeds against D-galactosamine/lipopolysaccharide induced hepatotoxicity in animal model.

Chemical/toxin1 linked therapy

2016

PMID 27914011Mouse

Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture.

Fracture1 linked therapy

2016

PMID 27928159Mouse

Effect of TREM-1 blockade and single nucleotide variants in experimental renal injury and kidney transplantation.

Ischaemia-reperfusion1 linked therapy

2016

PMID 27932075Rat

Non-enzymatic oxidized metabolite of DHA, 4(RS)-4-F-neuroprostane protects the heart against reperfusion injury.

Ischaemia-reperfusion1 linked therapy

2016

PMID 27959885Rat

Potassium Aspartate Attenuates Brain Injury Induced by Controlled Cortical Impact in Rats Through Increasing Adenosine Triphosphate (ATP) Levels, Na+/K+-ATPase Activity and Reducing Brain Edema.

TBI1 linked therapy

2016

PMID 27960090Mouse

Critical Role of the CXCL10/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush.

Crush1 linked therapy

2016

PMID 27960618Mouse

Histologic changes of mesenchymal stem cell repair of tympanic membrane perforation.

Wound1 linked therapy

2016

PMID 27975299Rat

Nilotinib, a tyrosine kinase inhibitor exhibits protection against acute pancreatitis-induced lung and liver damage in rats.

Chemical/toxin1 linked therapy

2016

PMID 27977787Mixed

Modulating the Biologic Activity of Mesenteric Lymph after Traumatic Shock Decreases Systemic Inflammation and End Organ Injury.

Haemorrhage/shock1 linked therapy

2016

PMID 27986254Mouse

Inhibition of Na-K-Cl cotransporter isoform 1 reduces lung injury induced by ischemia-reperfusion.

Ischaemia-reperfusion1 linked therapy

2016

PMID 27992530Mouse

Anti-Inflammatory Effects of Rosiglitazone in Obesity-Impaired Wound Healing Depend on Adipocyte Differentiation.

Wound1 linked therapy

2016

PMID 27996966Mouse

Adenovirus-mediated Foxp3 expression in lung epithelial cells ameliorates acute radiation-induced pneumonitis in mice.

Radiation1 linked therapy

2016

PMID 27999379Mouse

Alginate Oligosaccharide Prevents Acute Doxorubicin Cardiotoxicity by Suppressing Oxidative Stress and Endoplasmic Reticulum-Mediated Apoptosis.

Chemical/toxin1 linked therapy

2016

PMID 28000945Rat

Histopathological and biochemical comparisons of the protective effects of amifostine and l-carnitine against radiation-induced acute testicular toxicity in rats.

Radiation1 linked therapy

2016

PMID 28004950Rat

Stimulation of 5-HT2A receptors recovers sensory responsiveness in acute spinal neonatal rats.

Spinal cord injury1 linked therapy

2016

PMID 28007523Mouse

Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia.

Haemorrhage/shock1 linked therapy

2016

PMID 28011621Mouse

A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors.

Radiation1 linked therapy

2016

PMID 28028070Mouse

Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression.

Other1 linked therapy

2016

PMID 28029115Mouse

Development of Orally Administered gamma-Tocotrienol (GT3) Nanoemulsion for Radioprotection.

Radiation1 linked therapy

2016

PMID 28031154Mouse

Single Administration of a Sustained-Release Formulation of KB-R7785 Inhibits Tympanic Membrane Regeneration in an Animal Model.

Other1 linked therapy

2016

PMID 28032304Rat

L-carnitine reduces susceptibility to bupivacaine-induced cardiotoxicity: an experimental study in rats.

Chemical/toxin1 linked therapy

2016

PMID 28040362Mouse

Role of the NLRP3 inflammasome in a model of acute burn-induced pain.

Burn1 linked therapy

2016

PMID 28040363Rat

Wound-healing promoting effect of total tannins from Entada phaseoloides (L.) Merr. in rats.

Wound1 linked therapy

2016

PMID 28057459Mixed

Parabrachial Pituitary Adenylate Cyclase-Activating Polypeptide Activation of Amygdala Endosomal Extracellular Signal-Regulated Kinase Signaling Regulates the Emotional Component of Pain.

Crush1 linked therapy

2016

PMID 28074457Rat

The acute effects of thymoquinone on acute peripheral nerve injury: an experimental study.

Crush1 linked therapy

2016

PMID 28078024Mouse

Neuroprotective effect of picroside II in brain injury in mice.

TBI1 linked therapy

2016

PMID 28105252Rat

Nephroprotective Effects of N-Acetylcysteine Amide against Contrast-Induced Nephropathy through Upregulating Thioredoxin-1, Inhibiting ASK1/p38MAPK Pathway, and Suppressing Oxidative Stress and Apoptosis in Rats.

Chemical/toxin1 linked therapy

2016

PMID 28105306Rat

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury.

Spinal cord injury1 linked therapy

2016

PMID 28170176Rat

Exosomes Derived from Akt-Modified Human Umbilical Cord Mesenchymal Stem Cells Improve Cardiac Regeneration and Promote Angiogenesis via Activating Platelet-Derived Growth Factor D

Ischaemia-reperfusion1 linked therapy

2016

PMID 28332435Rat

Mild Acute Intermittent Hypoxia Improves Respiratory Function in Unanesthetized Rats With Midcervical Contusion.

Spinal cord injury1 linked therapy

2016

PMID 28417085Mouse

Hepatoprotective standardized EtOH-water extract from the seeds of Fraxinus rhynchophylla Hance.

Chemical/toxin1 linked therapy

2016

PMID 28471121Rat

Zingiber officinale Roscoe ameliorates anticancer antibiotic doxorubicin-induced acute cardiotoxicity in rat.

Chemical/toxin1 linked therapy

2016

PMID 28955553Rat

Effects of different suture materials on tissue healing.

Wound1 linked therapy

2016

PMID 29889447Rat

IMMUNOMODULATORY EFFECT OF ALLOGENEIC MESENCHYMAL STEM CELLS OF RATS.

Wound1 linked therapy

2016

PMID 30084568Rat

Effect of ethanolic extract of Cyperus rotundus L. against isoprenaline induced cardiotoxicity.

Chemical/toxin1 linked therapy

2016

PMID 33440518Rat

Angiogenic Heparin-Mimetic Peptide Nanofiber Gel Improves Regenerative Healing of Acute Wounds.

Wound1 linked therapy

2016

PMID 33465882Mouse

Delivery of Flightless I siRNA from Porous Silicon Nanoparticles Improves Wound Healing in Mice.

Wound1 linked therapy

1,951–2,000 of 4,095

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The full review includes 5,033 publications. This searchable index represents the itemised subset; the 1990–2010 window is partially indexed. Extraction details are retained per therapy association.