The deleterious effects of high dose cimetidine in acute thermal injury.
RatBurnUnspecifiedSprague-DawleyMale200 mg/kgBefore and after burn
Model: 30 per cent full-thickness thermal burn
No beneficial effect was demonstrated. Cimetidine increased water content in lung, stomach and eschar, did not alter serum or urine electrolytes or extrarenal water loss, reduced the serum hyperosmolality seen in unresuscitated burned animals, and multiple post-burn doses were associated with a sig…
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