Evaluation of Excipient Effects on BCS Class 3 Drug Cimetidine
Healthy
Enrolment: 25 · Results not recorded
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Drug · Histamine H2 receptor antagonist (ANTAGONIST, direct interaction, disease efficacy true)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Healthy
Enrolment: 25 · Results not recorded
Kidney Cancer · Melanoma (Skin)
Enrolment: 30 · Results not recorded
COPD
Enrolment: 25 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Gastric ulcer induced by subserosal acetic acid injection, confirmed endoscopically on day 3
Collagenase activity rose at the acute ulcer stage while prolylhydroxylase rose during healing. Cimetidine did not alter prolylhydroxylase but tended to increase collagenase activity, whereas elcatonin increased prolylhydroxylase with little effect on collagenase.
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Model: Cervical spinal cord transection producing extensive linear erosions of the glandular stomach within 12 hours; treatment of established erosions
Both cimetidine and 16,16-dimethyl prostaglandin E2 significantly inhibited progression of gastric erosions compared with saline controls (p less than 0.05). A significant decrease in acid output (p less than 0.05) occurred only in the cimetidine group. The authors concluded both agents can arrest…
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Model: 30 per cent full-thickness thermal burn
No beneficial effect was demonstrated. Cimetidine increased water content in lung, stomach and eschar, did not alter serum or urine electrolytes or extrarenal water loss, reduced the serum hyperosmolality seen in unresuscitated burned animals, and multiple post-burn doses were associated with a sig…
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Model: Subacute gastric ulcer produced by transoral catheter-guided needle puncture of the gastric wall under ether anaesthesia in fasted rats
Cimetidine, famotidine, pirenzepine and sucralfate dose-dependently and significantly increased the healing rate of subacute gastric ulcers. Naproxen, piroxicam, indomethacin and ibuprofen significantly delayed healing, acetylsalicylic acid had no significant effect, and 0.5 molar hydrochloric acid…
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Model: Cervical spinal cord transection producing acute stress erosions of the glandular stomach
16,16-dimethyl prostaglandin E2 and antacid both significantly reduced mean ulcer length at 8 hours compared with controls (P less than 0.05), whereas cimetidine had no significant effect on erosions despite significantly reducing gastric acid output relative to both the prostaglandin and control g…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.