Trauma-induced glial proliferation: possible involvement of the immune system.
RatTBIUnspecifiedInbred rats, strain not specifiedMaleMethotrexate intraperitoneal; hydrocortisone intramuscularMethotrexate 2.5 and 10 mg/kg/day; hydrocortisone 100 mg/kg…Five days of pretreatment before cortical lesioning; a separate arm gave methot…
Model: Mechanical lesion of the frontal cortex
Methotrexate pretreatment reduced tritiated thymidine incorporation into cortical DNA, indicating suppressed glial proliferation, and also reduced haemagglutination titres and thymus and spleen weights. Hydrocortisone produced comparable immunosuppression but a much smaller effect on thymidine inco…
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