Methotrexate Single-dose vs Methotrexate/Actinomycin-D in Low-Risk Gestational Trophoblastic Neoplasia
Gestational Trophoblastic Disease · Gestational Trophoblastic Neoplasia
Enrolment: 300 · Results not recorded
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Drug · Dihydrofolate reductase inhibitor
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Gestational Trophoblastic Disease · Gestational Trophoblastic Neoplasia
Enrolment: 300 · Results not recorded
Uveitis, Anterior · Adalimumab
Enrolment: 50 · Results not recorded
Atherosclerotic Cardiovascular Disease · Vascular Inflammation
Enrolment: 123 · Results not recorded
Leukemia · Myelodysplastic Syndromes · Myelodysplastic/Myeloproliferative Neoplasms
Enrolment: 254 · Results not recorded
Rheumatoid Arthritis
Enrolment: 276 · Results not recorded
Acute Myeloid Leukemia · GvHD prophylaxis
Enrolment: 101 · Results not recorded
Dermatomyositis
Enrolment: 75 · Results not recorded
Rheumatoid Arthritis
Enrolment: 70 · Results not recorded
Lymphoma
Enrolment: 1 · Results not recorded
Graft Versus Host Disease
Enrolment: 52 · Results not recorded
Graft vs Host Disease · Hematologic Neoplasms
Enrolment: 26 · Results not recorded
Rheumatoid Arthritis (RA)
Enrolment: 49 · Results not recorded
Leukemia · Myeloma
Enrolment: 3 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Thoracic laminectomy followed by temporary aneurysm clip compression spinal cord injury
Low-dose methotrexate reduced lipid peroxidation in the subacute stage only. It did not improve histopathological grade at either stage and neither methotrexate nor methylprednisolone reduced myeloperoxidase activity.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Mechanical lesion of the frontal cortex
Methotrexate pretreatment reduced tritiated thymidine incorporation into cortical DNA, indicating suppressed glial proliferation, and also reduced haemagglutination titres and thymus and spleen weights. Hydrocortisone produced comparable immunosuppression but a much smaller effect on thymidine inco…
Extraction: extract · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.
Model: Irradiation of the cervical spinal cord producing early delayed white matter necrosis and late delayed vascular syndromes
Intrathecal ara-C given shortly before irradiation reduced isoeffect doses for early delayed white matter necrosis by a factor of 1.2 to 1.3 and appeared to impair long-term regeneration, with no effect on the late delayed vascular syndrome. The effect disappeared when ara-C was given intravenously…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Spinal cord injury by 50 g/cm weight drop trauma
Methotrexate significantly reduced myeloperoxidase activity and malondialdehyde level in the first 24 h and was more effective than methylprednisolone; it better preserved large and medium diameter myelinated axons and produced no neurotoxicity in uninjured cord.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Laminectomy followed by spinal cord injury induced with a temporary aneurysm clip compression
Neither methotrexate nor methylprednisolone reduced the histopathological damage grade at either stage, although low-dose methotrexate lowered lipid peroxidation in the sub-acute stage and was reported as more effective than methylprednisolone.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.