The radiosensitizing effect of ornidazole in hypoxic mammalian tissue: an in vivo study.
MouseRadiationC57BLMale and femaleIntraperitoneal500 mg/kg, 100 mg/kg and 20 mg/kgBefore irradiation
Model: Abdominal irradiation at 9 to 24 Gy with acute killing assessed 4 to 6 days later, under air, oxygen or nitrogen breathing
In nitrogen-breathing mice ornidazole reduced the LD50 from 24.39 (SD 5.66) Gy to 16.38 (SD 1.86) Gy at 500 mg/kg and 18.04 (SD 2.48) Gy at 100 mg/kg, giving enhancement ratios of 1.48 (SD 0.25) and 1.35 (SD 0.27) and relative sensitising efficiencies of 40 and 29 per cent. No sensitisation occurre…
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