Levornidazole vs ornidazole for postoperative intra-abdominal anaerobic infections
Intraabdominal Infections
Enrolment: 696 · Results not recorded
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Drug · Produces reactive intermediates; mechanism not fully elucidated. 5-nitroimidazole antiprotozoal/antibacterial
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Intraabdominal Infections
Enrolment: 696 · Results not recorded
Rectal Cancer Surgery
Enrolment: 414 · Results not recorded
Elective Colorectal Surgery
Enrolment: 920 · Results not recorded
Colon Cancer
Enrolment: 193 · Results not recorded
Irritable Bowel Syndrome
Enrolment: 96 · Results not recorded
Chronic Constipation
Enrolment: 96 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Abdominal irradiation at 9 to 24 Gy with acute killing assessed 4 to 6 days later, under air, oxygen or nitrogen breathing
In nitrogen-breathing mice ornidazole reduced the LD50 from 24.39 (SD 5.66) Gy to 16.38 (SD 1.86) Gy at 500 mg/kg and 18.04 (SD 2.48) Gy at 100 mg/kg, giving enhancement ratios of 1.48 (SD 0.25) and 1.35 (SD 0.27) and relative sensitising efficiencies of 40 and 29 per cent. No sensitisation occurre…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.