Effects of antacids, cimetidine, and 16,16-dimethyl prostaglandin E2 on acute gastric erosions in a spinal rat.
RatSpinal cord injuryComplete transectionInbred rats, strain not specifiedCimetidine and 16,16-dimethyl prostaglandin E2 intraperitoneal; antacid intragastricCimetidine 50 mg/kg; 16,16-dimethyl prostaglandin E2 10 mic…At 0 and 4 hours after cord transection
Model: Cervical spinal cord transection producing acute stress erosions of the glandular stomach
16,16-dimethyl prostaglandin E2 and antacid both significantly reduced mean ulcer length at 8 hours compared with controls (P less than 0.05), whereas cimetidine had no significant effect on erosions despite significantly reducing gastric acid output relative to both the prostaglandin and control g…
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