Acute and progressive lung injury after contact with phorbol myristate acetate.
RatChemical/toxinMale
Model: Instillation of phorbol myristate acetate into the airways producing acute and then progressive lung injury
Phorbol myristate acetate produced dose-dependent, neutrophil-independent alveolar and interstitial lung injury that was inhibited by catalase but not by superoxide dismutase, implicating hydrogen peroxide as the main mediator. The injury progressed to an interstitial fibrotic reaction by the sixth…
Extraction: extract · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.