THERAPY DOSSIER · th-cd9f481046c2

Catalase, compared with superoxide dismutase

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 7065123 ↗1982Reported benefit

Acute and progressive lung injury after contact with phorbol myristate acetate.

RatChemical/toxinMale

Model: Instillation of phorbol myristate acetate into the airways producing acute and then progressive lung injury

Phorbol myristate acetate produced dose-dependent, neutrophil-independent alveolar and interstitial lung injury that was inhibited by catalase but not by superoxide dismutase, implicating hydrogen peroxide as the main mediator. The injury progressed to an interstitial fibrotic reaction by the sixth…

Extraction: extract · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.

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