Radiation-induced acute necrosis of the pancreatic islet and the diabetic syndrome in th golden hamster (Mesocricetus auratus).
HamsterRadiationFemaleInjectionAfter irradiation, once the diabetic syndrome developed
Model: Exposure to 35,000 rad X-rays causing acute necrosis of pancreatic islet cells within 4 hours and a lethal diabetic syndrome
Irradiated hamsters developed hyperglycaemia, hyperkalaemia, ketonaemia and acidosis from 12 hours and died at 56 (SD 8) hours, with loss of beta-cell granules and reduced plasma insulin. Insulin injections reduced blood glucose and prolonged survival to about 5 days.
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