Effects of Fenofibrate on Adipocytokine Levels In Hypertriglyceridemic Patients
Hypertriglyceridemia
Enrolment not recorded · Results not recorded
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Hormone · Insulin receptor agonist (AGONIST; direct interaction)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Hypertriglyceridemia
Enrolment not recorded · Results not recorded
Type 1 Diabetes Mellitus
Enrolment: 48 · Results not recorded
Type 1 Diabetes Mellitus
Enrolment: 30 · Results not recorded
Type 1 Diabetes Mellitus
Enrolment: 9 · Results not recorded
Adrenal Insufficiency
Enrolment: 22 · Results not recorded
Hepatitis · Liver Cirrhosis · Hepatocellular Carcinoma
Enrolment: 210 · Results not recorded
Diabetes
Enrolment: 101 · Results not recorded
Type 2 Diabetes
Enrolment: 48 · Results not recorded
Type 2 Diabetes Mellitus
Enrolment: 130 · Results not recorded
Heart Diseases · Cardiovascular Disease
Enrolment: 110 · Results not recorded
8 studies reported at therapy level; 8 evidence entries itemised.
Model: Moderate lateral (parasagittal) fluid percussion injury, using a 5 mm craniotomy 1 mm right of the sagittal suture midway between bregma and lambda, with injury delivered by a fluid percussion device
Hippocampal synapses became chronically insulin resistant after lateral fluid percussion injury, with significantly reduced insulin receptor responsiveness at 7 days, 1 month and 3 months post-injury in both hemispheres, reduced ipsilateral synaptic insulin receptor level at 7 days followed by an i…
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Model: Dorsal skin wound incision in experimental diabetes
Tight insulin glycaemic control improved wound tensile strength, hydroxyproline and TGF-beta1 versus poorly controlled diabetic rats.
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Model: scald burn (92 C water, 18 s) with acute lung injury
Intensive insulin treatment attenuated burn-induced lung injury by protecting microvascular endothelium and reducing apoptosis.
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Model: Exposure to 35,000 rad X-rays causing acute necrosis of pancreatic islet cells within 4 hours and a lethal diabetic syndrome
Irradiated hamsters developed hyperglycaemia, hyperkalaemia, ketonaemia and acidosis from 12 hours and died at 56 (SD 8) hours, with loss of beta-cell granules and reduced plasma insulin. Insulin injections reduced blood glucose and prolonged survival to about 5 days.
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Model: Lipopolysaccharide-induced acute lung injury, LPS serotype O111:B4 at 5 mg/kg in 50 ul by one-time intratracheal injection, without hyperglycaemia
Insulin reduced lavage protein, cell and neutrophil counts, epithelial permeability, lung injury score, wet to dry ratio and apoptosis and increased alveolar fluid clearance by 93% through increased ENaC expression and SGK1 phosphorylation, without altering blood glucose.
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Model: Scald burn injury covering 45 per cent of total body surface area
Insulin for four days increased the volume fraction of thin collagen and of elastic fibres and stimulated re-epithelialisation in burned rats, with a new muscle layer visible at 14 days. Untreated burned animals had a higher volume fraction of thick collagen at four days whereas insulin-treated ani…
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Model: Streptozotocin-induced diabetic rats subjected to full-thickness excisional skin wounds (four 8 mm biopsy punch wounds on the dorsum) and, in a parallel model, subcutaneous implantation of four sterile polyvinyl alcohol sponges via 1 cm dorsal incisions
Diabetes slowed healing (1.2 versus 1.62 mm/day in controls, P<0.05) and increased granulation tissue NGAL and MMP-9, implant neutrophil NGAL and MMP-9, wound fluid active MMP-9 and NGAL/MMP-9 complex, and circulating neutrophil NGAL, MMP-9 and MMP-8. Daily insulin from diabetes onset restored heal…
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Model: Full-thickness burn covering 40 per cent of total body surface area
Burn injury produced two hyperglycaemic peaks at 0.5 h and 3 h, with acute insulin resistance at 3 h that correlated positively with mortality. Serum carboxymethyllysine rose within 1 h, preceding insulin resistance. Both sRAGE treatment and early glycaemic control with insulin alleviated postburn…
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