Treatment of established spinal injury-induced gastric erosions in rats with cimetidine and 16,16-dimethyl prostaglandin E2.
RatSpinal cord injuryComplete transectionSprague-DawleyMaleIntraperitonealCimetidine 25 mg/kg; 16,16-dimethyl prostaglandin E2 5 micr…Treatment began 12 hours after cord transection, once erosions were established
Model: Cervical spinal cord transection producing extensive linear erosions of the glandular stomach within 12 hours; treatment of established erosions
Both cimetidine and 16,16-dimethyl prostaglandin E2 significantly inhibited progression of gastric erosions compared with saline controls (p less than 0.05). A significant decrease in acid output (p less than 0.05) occurred only in the cimetidine group. The authors concluded both agents can arrest…
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