Non-specific stimulation of host defenses against a bacterial challenge in malnourished hosts.
MouseWound24 hours before bacterial challenge
Model: Klebsiella pneumoniae-laden suture simulating a surgical wound infection, in mice made malnourished by 48 hours of acute starvation or 2 weeks of protein deprivation
Muramyl dipeptide given 24 hours before challenge produced statistically lower local and systemic bacterial recovery and improved short-term survival compared with untreated controls in both the starvation and protein-deprivation models, substantially reversing the effect of malnutrition on host de…
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