Mifamurtide combined with post-operative chemotherapy in newly diagnosed high-risk osteosarcoma
Osteosarcoma
Enrolment: 60 · Results not recorded
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Biologic · No ChEMBL mechanism_of_action record. MDP is the minimal peptidoglycan adjuvant motif; ChEMBL max_phase 1.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Osteosarcoma
Enrolment: 60 · Results not recorded
Osteosarcoma
Enrolment: 8 · Results not recorded
Osteosarcoma
Enrolment: 205 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Klebsiella pneumoniae-laden suture simulating a surgical wound infection, in mice made malnourished by 48 hours of acute starvation or 2 weeks of protein deprivation
Muramyl dipeptide given 24 hours before challenge produced statistically lower local and systemic bacterial recovery and improved short-term survival compared with untreated controls in both the starvation and protein-deprivation models, substantially reversing the effect of malnutrition on host de…
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.