Healing of skin incision wounds treated with topically applied BAPN free base in the rat.
RatWoundMaleTopical (with intraperitoneal comparison for LD50)5, 20, 100 or 200 microlitres per application; LD50 in mice…
Model: Skin incision wound, with intact skin as a further comparison; acute LD50 determination in mice
Breaking strength of the skin wound and of intact skin was significantly reduced at 20 microlitres and higher, and body weight growth was significantly retarded at the two highest doses. Reduced breaking strength with increased collagen extractability indicated specific inhibition of collagen polym…
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