THERAPY DOSSIER · th-6beb3de5d68c

beta-Aminopropionitrile (BAPN) free base

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 6617824 ↗1983Reported harm

Healing of skin incision wounds treated with topically applied BAPN free base in the rat.

RatWoundMaleTopical (with intraperitoneal comparison for LD50)5, 20, 100 or 200 microlitres per application; LD50 in mice…

Model: Skin incision wound, with intact skin as a further comparison; acute LD50 determination in mice

Breaking strength of the skin wound and of intact skin was significantly reduced at 20 microlitres and higher, and body weight growth was significantly retarded at the two highest doses. Reduced breaking strength with increased collagen extractability indicated specific inhibition of collagen polym…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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