PebbleAtlas
PEBBLE / ATLAS
Open research access
PRECLINICAL PUBLICATION · 1984

Supplemental vitamin A prevents the acute radiation-induced defect in wound healing.

Rat / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 6385875 ↗1984Reported benefit

Supplemental vitamin A prevents the acute radiation-induced defect in wound healing.

RatRadiationSprague-DawleyMaleOral (dietary)150,000 IU vitamin A per kg diet supplemented on top of a c…Started at, 2 or 4 days before, or 1 to 2 hours to 4 days after irradiation and…

Model: Acute whole-body irradiation (175 to 850 rad) combined with dorsal skin incision and subcutaneous polyvinyl alcohol sponge implantation

Supplemental vitamin A prevented the impaired wound healing and lessened weight loss, leukopenia, thrombocytopenia, thymic involution, adrenal enlargement, reduction in splenic weight and gastric ulceration in rats irradiated at 750 to 850 rad and wounded. The benefit was seen whether supplementati…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.