THERAPY DOSSIER · th-7d1a247ca55b

Vitamin A

Nutraceutical · No ChEMBL mechanism_of_action record. ATC A11CA01 (vitamin A), D10AD02, S01XA02, R01AX02.

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Evidence & regulatory context

Mechanism: No ChEMBL mechanism_of_action record. ATC A11CA01 (vitamin A), D10AD02, S01XA02, R01AX02.
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: 1982
Development stage: Not recorded
ChEMBL record: CHEMBL986 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Vitamin A; Vitamin A 1; Retinol; Arovit; Ro-a-vit; NSC-122759
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00363038 ↗NAcompleted

Topical vitamin K, vitamin K and retinol, and arnica on post-laser bruising

Ecchymosis

Enrolment: 16 · Results not recorded

NCT03248700 ↗NAcompleted

Vitamin A kinetics and mathematical modeling in American women

Vitamin A Kinetics

Enrolment: 8 · Results not recorded

NCT01922713 ↗NAcompleted

Beta-carotene biofortified maize on milk retinol in lactating Zambian women

Vitamin A Deficiency

Enrolment: 149 · Results not recorded

Preclinical evidence 2

2 studies reported at therapy level; 2 evidence entries itemised.

PMID 6385875 ↗1984Reported benefit

Supplemental vitamin A prevents the acute radiation-induced defect in wound healing.

RatRadiationSprague-DawleyMaleOral (dietary)150,000 IU vitamin A per kg diet supplemented on top of a c…Started at, 2 or 4 days before, or 1 to 2 hours to 4 days after irradiation and…

Model: Acute whole-body irradiation (175 to 850 rad) combined with dorsal skin incision and subcutaneous polyvinyl alcohol sponge implantation

Supplemental vitamin A prevented the impaired wound healing and lessened weight loss, leukopenia, thrombocytopenia, thymic involution, adrenal enlargement, reduction in splenic weight and gastric ulceration in rats irradiated at 750 to 850 rad and wounded. The benefit was seen whether supplementati…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

PMID 20970494 ↗2010Reported benefit

Marked changes in endogenous antioxidant expression precede vitamin A-, C-, and E-protectable, radiation-induced reductions in small intestinal nutrient transport.

MouseRadiationMaleOralBefore irradiation

Model: Acute gamma-irradiation of small intestine

Pre-irradiation antioxidant vitamins prevented radiation-induced reductions in intestinal nutrient transport.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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