The time course of radioprotection by WR 2721 in mouse skin.
MouseRadiationBALB/cMaleIntravenous or intraperitoneal400 mg/kg5, 10, 15, 30 and 60 minutes before irradiation
Model: Single-dose electron beam irradiation of the hind leg at 20 to 60 Gy and 13 to 17 Gy/min producing acute skin desquamation
Dose modifying factors of 1.7 to 2.1 were obtained when WR-2721 was given 30 to 60 minutes before irradiation, compared with only 1.1 to 1.3 at 5 minutes and intermediate values at 10 and 15 minutes. Factors rose slightly faster and to slightly higher values after intravenous than intraperitoneal i…
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