Protective effects of S-2-(3-aminopropylamino)ethylphosphorothioic acid against radiation damage of normal tissues and a fibrosarcoma in mice.
MouseRadiationC3Hf/KamMale and femaleBefore irradiation, with protection dependent on the interval between administr…
Model: Single-dose gamma irradiation causing acute damage to jejunum, testis, lung and hair follicles, with a syngeneic fibrosarcoma also assessed
WR-2721 increased radioresistance of jejunal epithelial cells by a factor of 1.64 and of spermatogenic cells by 1.54, with a smaller factor of 1.24 for hair loss. It did not reduce radiation-induced acute lung damage as measured by lung tumour nodule formation and instead augmented the radiation-in…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.