The effect of "Unguentum lymphaticum" on acute experimental lymphedema and other high-protein edemas.
RatOtherTopical (cream)
Model: Acute lymphoedema of the rat leg, plus dextran and burn oedema models, with and without macrophage poisoning by silica
The cream was very effective in lymphoedema, completely preventing the 36 per cent increase in leg volume seen with the drug-free base. Protection was much reduced when macrophages were selectively poisoned with silica and oedema reached maximum volume more rapidly, indicating most activity is via…
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