Efficacy and Safety of Fixed-dose Coumarin and Troxerutin (Venalot) Versus Placebo in Chronic Venous Insufficiency (VENACT)
Chronic Venous Insufficiency
Enrolment: 829 · Results not recorded
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Nutraceutical · Coumarin induces proteolysis of high-molecular-weight proteins present in lymphedema. Small-size protein fragments can then be more easily drained via the lymphatics. The oncotic pressure drops and edema lessens.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Chronic Venous Insufficiency
Enrolment: 829 · Results not recorded
Psoriasis Vulgaris · Topical Administration
Enrolment: 88 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Rat leg and foot oedema produced by lymphostasis, moderate burns or dextran, compared with normal tissue
The cream greatly reduced oedema in legs with lymphostasis and greatly reduced tissue and initial lymphatic plasma protein concentrations and total tissue protein, consistent with removal of excess protein through an increase in macrophage numbers and proteolysis. In the rat foot the cream increase…
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Model: Acute lymphoedema of the rat leg, plus dextran and burn oedema models, with and without macrophage poisoning by silica
The cream was very effective in lymphoedema, completely preventing the 36 per cent increase in leg volume seen with the drug-free base. Protection was much reduced when macrophages were selectively poisoned with silica and oedema reached maximum volume more rapidly, indicating most activity is via…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.