Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea.
RatOther10 mM in vitro and in the isolated perfused lung; 500 mg/kg…
Model: Two models: isolated rat lung perfused with activated polymorphonuclear leukocytes producing hydroxyl radical, and intact rats exposed to 100 per cent oxygen for 66 hours (hyperoxic lung injury)
Dimethylthiourea at 10 mM blocked 79 per cent of hydroxyl radical production by polymorphonuclear leukocytes without affecting superoxide production, myeloperoxidase activity, chemotaxis, degranulation or aggregation. In isolated lungs perfused with activated leukocytes, lung weight rose from 2.3 p…
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