Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Other
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatOtherMalePretreatment before hyperoxic exposure
Model: Normobaric hyperoxia for 48 h or more causing acute oedematous lung injury
Hyperoxia raised blood acid-soluble sulfhydryl levels in parallel with lung oxidised glutathione and GSSG-to-GSH ratio. Pretreatment with dimethylthiourea reduced the rises in blood sulfhydryl, haematocrit, pleural effusion volume, lung GSSG and GSSG-to-GSH ratio.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
RatOther10 mM in vitro and in the isolated perfused lung; 500 mg/kg…
Model: Two models: isolated rat lung perfused with activated polymorphonuclear leukocytes producing hydroxyl radical, and intact rats exposed to 100 per cent oxygen for 66 hours (hyperoxic lung injury)
Dimethylthiourea at 10 mM blocked 79 per cent of hydroxyl radical production by polymorphonuclear leukocytes without affecting superoxide production, myeloperoxidase activity, chemotaxis, degranulation or aggregation. In isolated lungs perfused with activated leukocytes, lung weight rose from 2.3 p…
Extraction: extract · Supplied extraction confidence: 0.82. Machine-extracted fields require source verification.
