The effects of diosmin (a benzo-pyrone) upon some high-protein oedemas: lung contusion, and burn and lymphoedema of rat legs.
RatOtherMaleOral50 or 200 mg/kg/day
Model: Three models in one report: direct blunt trauma lung contusion; burn oedema of the rat foot; acute lymphoedema of the rat leg produced by lymphostasis
Diosmin considerably reduced interstitial oedema, tissue disorganisation and interstitial and air-space protein concentration in contused lung, with a greater effect at 200 than 50 mg/kg. In the oedema models the low dose (50 mg/kg) reduced burn oedema whereas the high dose (200 mg/kg) did not; bot…
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