Mediators of lung injury in mice following systemic activation of complement.
MouseChemical/toxinC57BL (including C5-deficient and beige mice)Male
Model: Acute lung injury induced by intravenous cobra venom factor causing systemic complement activation
Catalase gave a marked degree of protection from lung injury whereas superoxide dismutase gave only limited protection, implicating hydrogen peroxide or its derivatives. Lipoxygenase and thromboxane synthetase inhibitors afforded some protection while cyclooxygenase inhibitors gave variable results…
Extraction: extract · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.