SOD as Antioxidant Treatment of ARMD
Age Related Macular Degeneration
Enrolment: 46 · Results not recorded
Loading the evidence…
Biologic · Composite intervention set (enzymes plus several enzyme-inhibitor classes); no single confident ChEMBL entity, so unresolved. Trials listed are superoxide dismutase agents only, from an 'superoxide dismutase' intervention query; flagged for manual review.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Age Related Macular Degeneration
Enrolment: 46 · Results not recorded
Healthy Volunteers
Enrolment: 28 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Acute lung injury induced by intravenous cobra venom factor causing systemic complement activation
Catalase gave a marked degree of protection from lung injury whereas superoxide dismutase gave only limited protection, implicating hydrogen peroxide or its derivatives. Lipoxygenase and thromboxane synthetase inhibitors afforded some protection while cyclooxygenase inhibitors gave variable results…
Extraction: extract · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.
Model: Acute thermal injury to rat skin at 70 degrees C for 30 seconds, with remote acute lung injury
Thermal injury produced progressive consumptive depletion of complement, appearance of C5a-related chemotactic activity in serum within the first hour with associated neutropenia, and progressive lung permeability increases over 6 hours. Protection from lung injury was afforded by complement deplet…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.