Protective effect of vitamin E in rats with acute liver injury.
RatChemical/toxinmaleOral, as dietary supplementation300 mg DL-alpha-tocopherol per kg dietSupplementation started 6 days before D-galactosamine administration
Model: Acute liver injury induced by D-galactosamine 1.5 to 2.0 g/kg body weight intraperitoneally, in conventional and germ-free rats
Vitamin E supplementation significantly improved both 5-day and 14-day survival and reduced liver fat and collagen accumulation and SGPT levels. The benefit was present in both conventional and germ-free rats with no significant difference between them, arguing against mediation by intestinal bacte…
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