Vitamin E

Alpha-tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation combined injury in mice.

Model: Bilateral cobalt-60 total body irradiation at 0.6 Gy/min, doses of 8, 9.2, 11, 11.5, 12.0, 12.5, 13.0 and 14.0 Gy; combined injury adds a non-lethal full thickness dorsal skin wound made with a 9/16 inch arch punch within 1 h after irradiation

Transfusion of mobilised peripheral blood mononuclear cells 24 h after irradiation significantly improved survival at 11.5, 12.0 and 12.5 Gy on day 10 and at 11.5 and 12.0 Gy on days 15 and 30, and both mobilised cells and alpha-tocopherol succinate alone improved survival after 9.2 Gy plus woundin…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

Vitamin E ameliorates iodine-induced cytotoxicity in thyroid.

Model: Iodine-induced thyroid cytotoxicity; goiter induced by 12-week low-iodine diet then twofold physiological dose of iodine in drinking water

Vitamin E supplementation partly ameliorated iodine-induced thyroid cytotoxicity, with a 50-fold dose optimal, but did not reduce involuting gland weight.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

Protective effect of vitamin E in rats with acute liver injury.

Model: Acute liver injury induced by D-galactosamine 1.5 to 2.0 g/kg body weight intraperitoneally, in conventional and germ-free rats

Vitamin E supplementation significantly improved both 5-day and 14-day survival and reduced liver fat and collagen accumulation and SGPT levels. The benefit was present in both conventional and germ-free rats with no significant difference between them, arguing against mediation by intestinal bacte…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

Vitamin E protects against monosodium glutamate-induced acute liver injury and hepatocyte ultrastructural alterations in rats.

Model: Monosodium glutamate-induced acute liver injury, 4 g/kg daily for 7 days, with sacrifice on day 8

Monosodium glutamate produced apoptotic hepatocytes with pyknotic nuclei, cytoplasmic vacuolation, swollen mitochondria, dilated endoplasmic reticulum and sinusoids, and collagen deposition. Vitamin E at 300 mg/kg substantially preserved liver tissue and hepatocellular architecture, with only parti…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

Preventative Effect of Vitamin E on Mast Cells in Carbon Tetrachlorideinduced Acute Liver Damage.

Model: Carbon tetrachloride induced acute liver damage

Vitamin E prevented the carbon tetrachloride induced rises in mast cell counts, malondialdehyde, degenerative parenchymal cells, steatosis and inflammation, preserving hepatic histological architecture.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

The effect of vitamin E and L-carnitine against methotrexate-induced injury in rat testis.

Model: Methotrexate-induced testicular injury, 20 mg/kg intraperitoneally on days 3 and 10 of a 17-day protocol

Methotrexate caused weight loss, testicular weight loss, marked histological injury, increased malondialdehyde and decreased superoxide dismutase. Vitamin E and L-carnitine did not prevent methotrexate-induced weight loss or testicular weight loss but inhibited the histological injury and suppresse…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

Dependence between the free-radical peroxidation, the activity of the superoxide dismutase glucose-6-phosphate dehydrogenase and erythrocytes haemolysis after thermal trauma and alpha-tocopherol treatment.

Model: Grade IIIa-IIIb thermal burn over 15-20% of body surface

Free-radical oxidation products and erythrocyte haemolysis rose in parallel after burn injury. Alpha-tocopherol reduced free-radical oxidation products and increased antioxidative protection and erythrocyte resistance during the acute postburn period.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

Excessive alpha-tocopherol exacerbates microglial activation and brain injury caused by acute ischemic stroke.

Model: Acute ischaemic stroke

Supraphysiologic brain alpha-tocopherol exacerbated ischaemic stroke-induced brain injury, with increased cortical S100B and RAGE at 48 hours, aggravated microglial activation and neuroinflammatory signalling, and increased markers of oxidative injury and neurodegeneration.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

Radioprotective properties of tocopherol succinate against ionizing radiation in mice.

Model: Whole body bilateral cobalt-60 gamma irradiation at 0.6 Gy/min; 11 Gy for jejunal histology and immunohistochemistry endpoints and 9.2 Gy for the comet assay

Subcutaneous tocopherol succinate given 24 h before lethal gamma irradiation reduced jejunal CD68-positive inflammatory cells, DNA damage in blood, spleen and thymus cells and apoptotic markers, while increasing phospho-histone H3 and proliferating cell nuclear antigen positive crypt cells.

Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

Marked changes in endogenous antioxidant expression precede vitamin A-, C-, and E-protectable, radiation-induced reductions in small intestinal nutrient transport

Model: Acute gamma-irradiation of small intestine

Pre-irradiation antioxidant vitamins prevented radiation-induced reductions in intestinal nutrient transport.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

Preclinical development of a bridging therapy for radiation casualties

Extraction: mesh. Machine-extracted fields require source verification.

Treatment with dexamethasone or liposome-encapsuled vitamin E provides beneficial effects after chemical-induced lung injury

Extraction: mesh. Machine-extracted fields require source verification.

Biochemical and histopathologic effects of omeprazole and vitamin E in rats with corrosive esophageal burns

Extraction: mesh. Machine-extracted fields require source verification.

Protective effect of nitric oxide synthase inhibition or antioxidants on brain oxidative damage caused by intracerebroventricular arginine administration

Extraction: mesh. Machine-extracted fields require source verification.

Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice

Extraction: mesh. Machine-extracted fields require source verification.

Beneficial effects of vitamin E in sperm functions in the rat after spinal cord injury

Extraction: mesh. Machine-extracted fields require source verification.

Effects of topical L-selenomethionine with topical and oral vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice

Extraction: mesh. Machine-extracted fields require source verification.

New strategies for the prevention of radiation injury: possible implications for countering radiation hazards of long-term space travel

Extraction: mesh. Machine-extracted fields require source verification.

Vitamin E reduces transendothelial migration of neutrophils and prevents lung injury in endotoxin-induced airway inflammation

Extraction: mesh. Machine-extracted fields require source verification.

Catalase and alpha-tocopherol attenuate blood-brain barrier breakdown in pentylenetetrazole-induced epileptic seizures in acute hyperglycaemic rats

Extraction: mesh. Machine-extracted fields require source verification.

In vivo radioprotection by alpha-TMG: preliminary studies

Extraction: mesh. Machine-extracted fields require source verification.

Silicone rubber microangiography of injured acute spinal cord after treatment with methylprednisolone and vitamin E in rats

Extraction: mesh. Machine-extracted fields require source verification.

Topical application of alpha-tocopherol modulates the antioxidant network and diminishes ultraviolet-induced oxidative damage in murine skin

Extraction: mesh. Machine-extracted fields require source verification.

Alleviation of paraquat-induced lung injury by pretreatment with bifunctional liposomes containing alpha-tocopherol and glutathione

Extraction: mesh. Machine-extracted fields require source verification.

The potential synergistic effect of calcium channel blockers and alpha-tocopherol on gastric mucosal injury induced by ischaemia-reperfusion

Extraction: mesh. Machine-extracted fields require source verification.

Intestinal radioprotection by vitamin E (alpha-tocopherol)

Extraction: mesh. Machine-extracted fields require source verification.

Effect of vitamin E deficiency and supercritical fluid aerosolized vitamin E supplementation on interleukin-1-induced oxidative lung injury in rats

Extraction: mesh. Machine-extracted fields require source verification.

Intestinal radioprotection by two new agents applied topically

Extraction: mesh. Machine-extracted fields require source verification.

Effects of topical and oral vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice

Extraction: mesh. Machine-extracted fields require source verification.