Beneficial effects of acute intravenous ibuprofen on neurologic recovery of head-injured mice: comparison of cyclooxygenase inhibition with inhibition of thromboxane A2 synthetase or 5-lipoxygenase.
MouseTBIWeight-drop / impact-accelerationCF-1MaleIntravenous1, 3, 10 or 30 mg/kgWithin 5 minutes after injury
Model: Moderately severe concussive closed head injury by weight drop, 900 g-cm (50 g weight dropped 18 cm)
Ibuprofen produced a dose-related improvement in early neurological recovery, with 10 mg/kg intravenously giving a 122 per cent increase in mean grip test score versus saline (p less than 0.01, one-way ANOVA) and significantly fewer severely impaired mice. Furegrelate, ciprostene and piriprost prod…
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