Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP)
Retinopathy of Prematurity
Enrolment: 14 · Results not recorded
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Drug · Cyclooxygenase inhibitor (INHIBITOR, direct interaction, disease efficacy true)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Retinopathy of Prematurity
Enrolment: 14 · Results not recorded
Healthy Subjects
Enrolment: 6 · Results not recorded
Healthy
Enrolment: 24 · Results not recorded
Osteoarthritis, Knee
Enrolment: 18 · Results not recorded
Acute Mountain Sickness · High Altitude Headache
Enrolment: 300 · Results not recorded
Preterm Labor
Enrolment: 11 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Full-thickness skin incision wound in nude mice
Both acellular and keratinocyte plus fibroblast seeded 20 wt % ibuprofen nanofibrous bandages reduced wound contraction relative to Tegaderm and sterile gauze. Newly regenerated skin under cell-seeded ibuprofen bandages showed significantly greater blood vessel formation than under acellular ibupro…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Moderately severe concussive closed head injury by weight drop, 900 g-cm (50 g weight dropped 18 cm)
Ibuprofen produced a dose-related improvement in early neurological recovery, with 10 mg/kg intravenously giving a 122 per cent increase in mean grip test score versus saline (p less than 0.01, one-way ANOVA) and significantly fewer severely impaired mice. Furegrelate, ciprostene and piriprost prod…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.
Model: Unilateral TGF-beta1-induced Achilles tendinopathy, with 100 ng active recombinant human TGF-beta1 injected into the mid-portion of the Achilles tendon on days 0 and 2
Ibuprofen blocked remodelling of the inflammatory hyaluronan matrix, induced aberrant vasculogenic cell groups and abnormal gene activation at day 28, and reduced tensile stiffness (p = 0.004) and elastic modulus (p = 0.012) in mice dosed from day 3 to day 25 whether injured or not.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Midline fluid percussion injury producing diffuse traumatic brain injury, righting reflex time 6 to 10 minutes
Acute over-the-counter analgesic administration neither attenuated nor exacerbated injury-induced functional deficits, and cortical cytokine levels were affected by injury and time but not by treatment at 6 or 24 hours.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Single moderate midline fluid percussion injury (1.9-2.0 atm)
Injury produced concomitant classical activation and acquired deactivation microglial phenotypes with raised MHC I, MHC II, TSPO, CD45 and TGF-beta1 at 7 days, and daily ibuprofen significantly reduced expression of these genes.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.