Effects of intrathecal methotrexate and cytosine arabinoside on the radiation tolerance of the rat spinal cord.
RatRadiationmaleIntrathecal, into the lumbar spinal canal, and intravenousMaximally tolerated intrathecal methotrexate dose; numerica…Shortly before irradiation, or 24 h after irradiation in comparison groups
Model: Irradiation of the cervical spinal cord producing early delayed white matter necrosis and late delayed vascular syndromes
Intrathecal ara-C given shortly before irradiation reduced isoeffect doses for early delayed white matter necrosis by a factor of 1.2 to 1.3 and appeared to impair long-term regeneration, with no effect on the late delayed vascular syndrome. The effect disappeared when ara-C was given intravenously…
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