Effect of omeprazole on acute gastric stress ulceration in cervical cord transected rats.
RatSpinal cord injuryComplete transectionInbred strain (not further specified)FemaleIntraduodenal1.725, 2.625, 3.5 and 17.5 mg/kg
Model: Acute cervical spinal cord transection with subsequent gastric stress ulceration
Omeprazole produced dose-dependent inhibition of gastric acid output, with complete achlorhydria at the highest dose. The quantity of ulceration was inversely proportional to dose, with nearly complete prevention at 17.5 mg/kg.
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