Esomeprazole 20 mg Once Daily Compared With Omeprazole 10 mg and Esomeprazole 10 mg in Maintenance Treatment of Healed Reflux Esophagitis
Reflux Esophagitis
Enrolment: 540 · Results not recorded
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Drug · Potassium-transporting ATPase inhibitor (gastric H+/K+-ATPase proton pump); alpha subunit is likely binding site
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Reflux Esophagitis
Enrolment: 540 · Results not recorded
Metabolism of Clopidogrel
Enrolment: 18 · Results not recorded
AOD Effects and Consequences
Enrolment: 16 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Acute cervical spinal cord transection with subsequent gastric stress ulceration
Omeprazole produced dose-dependent inhibition of gastric acid output, with complete achlorhydria at the highest dose. The quantity of ulceration was inversely proportional to dose, with nearly complete prevention at 17.5 mg/kg.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Cisplatin-induced acute kidney injury (15 mg/kg cisplatin intraperitoneally)
Omeprazole reduced cisplatin-induced apoptosis and structural kidney damage in vivo and in vitro and inhibited TLR4/NF-kappaB/NLRP3 signalling; the anti-inflammatory effect was blunted by LPS co-treatment in HK-2 cells.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Laser-induced microscopic injury to the gastric epithelium of the exposed gastric corpus in anaesthetised mice, with luminal superfusion at pH 2, 3, 5 or 7
Epithelial repair varied with luminal pH, being unreliable at pH 2 and slower at pH 7; at luminal pH 3 and pH 7 omeprazole reduced maximal damage size and accelerated repair, and famotidine did the same at pH 7, with benefits extending beyond simply raising luminal or surface pH and without a rise…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.