Failure of naloxone to improve spinal cord blood flow and cardiac output after spinal cord injury.
RatSpinal cord injuryCompressionfemaleIntravenous10 mg/kg intravenous bolus followed by intravenous infusion…Started after the 15 min post-injury measurement
Model: C7-T1 laminectomy followed by a 1 min acute compression injury at T-1 with a 50 g clip, in anaesthetised, paralysed and ventilated rats
Naloxone failed to improve post-traumatic spinal cord blood flow and did not prevent post-traumatic hypotension or the progressive decline in cardiac output between 15 and 75 min after injury, contradicting earlier reports of benefit in the weight-drop model.
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