Optimizing Patient Centered-Care: A Pragmatic Randomized Control Trial Comparing Models of Care in the Management of Prescription Opioid Misuse (OPTIMA Trial)
Opioid Use Disorder
Enrolment: 272 · Results not recorded
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Drug · Opioid receptors; mu/kappa/delta antagonist
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Opioid Use Disorder
Enrolment: 272 · Results not recorded
Opioid-Induced Constipation
Enrolment: 1500 · Results not recorded
Subjects With Moderate to Severe, Chronic Nonmalignant Pain
Enrolment: 463 · Results not recorded
Opioid-use Disorder
Enrolment: 100 · Results not recorded
Opioid Related Disorders · Opioid Dependence · Opioid Addiction
Enrolment: 106 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: C7-T1 laminectomy followed by a 1 min acute compression injury at T-1 with a 50 g clip, in anaesthetised, paralysed and ventilated rats
Naloxone failed to improve post-traumatic spinal cord blood flow and did not prevent post-traumatic hypotension or the progressive decline in cardiac output between 15 and 75 min after injury, contradicting earlier reports of benefit in the weight-drop model.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Hepatic ischaemia for 30 min followed by reperfusion, with remote kidney injury assessed at 24 h
Naloxone pretreatment reduced renal and hepatic histological damage and lowered malondialdehyde levels after hepatic ischaemia-reperfusion.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Standardised MASCIS (Multicenter Animal Spinal Cord Injury Study) contusive spinal cord injury
Naloxone produced negligible and statistically insignificant neuroprotection after contusive spinal cord injury. Mu-opioid receptor gene expression was upregulated in the brain but downregulated in the spinal cord after injury, which the authors propose explains the failure of naloxone in the NASCI…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.