The Combined Use of Curcumin and Platelet-Rich Plasma Enhances Axonal Regeneration in Acute Nerve Injuries: An Experimental Study in a Rat Model.
RatOtherHoltzman albinon = 32 rats, four groupsLocal platelet-rich plasma; intraperitoneal curcuminGiven at the time of acute nerve repair
Model: Right sciatic nerve transection with immediate surgical repair
The combined PRP and curcumin group showed significantly better clinical, electrophysiological and histological outcomes than the other three groups. Each adjuvant alone also improved outcomes over repair alone, with no significant difference between them.
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