Curcumin

An improvement in acute wound healing in mice by the combined application of photobiomodulation and curcumin-loaded iron particles.

Model: One full-thickness excisional round wound on the back of each mouse

Laser, curcumin nanoparticles and their combination accelerated wound closure and increased wound strength while reducing Staphylococcus aureus counts, with the combination superior to either treatment alone.

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Combined polymer-curcumin conjugate and ependymal progenitor/stem cell treatment enhances spinal cord injury functional recovery.

Model: Spinal cord contusion injury, acute and chronic stages

Polyacetal-curcumin improved neuroprotection, axonal growth and functional recovery in acute spinal cord injury, and combining it with ependymal stem/progenitor cells also improved recovery in a chronic injury model.

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Curcumin attenuates the expression and secretion of RANTES after spinal cord injury in vivo and lipopolysaccharide-induced astrocyte reactivation in vitro.

Model: impact spinal cord injury

Curcumin attenuated injury-induced RANTES and iNOS expression and lipid peroxidation after spinal cord injury.

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Curcumin immune-mediated and anti-apoptotic mechanisms protect against renal ischemia/reperfusion and distant organ induced injuries.

Model: renal ischaemia-reperfusion with distant (lung) organ injury

Curcumin pretreatment reduced systemic and tissue cytokines and pulmonary apoptosis after renal ischaemia-reperfusion.

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The Combined Use of Curcumin and Platelet-Rich Plasma Enhances Axonal Regeneration in Acute Nerve Injuries: An Experimental Study in a Rat Model.

Model: Right sciatic nerve transection with immediate surgical repair

The combined PRP and curcumin group showed significantly better clinical, electrophysiological and histological outcomes than the other three groups. Each adjuvant alone also improved outcomes over repair alone, with no significant difference between them.

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Nanotechnology in Wound Healing; Semisolid Dosage Forms Containing Curcumin-Ampicillin Solid Lipid Nanoparticles, in-vitro and in-vivo Characteristics.

Model: Second degree dorsal burn wound created with cylindrical iron devices of 2.5 cm2 surface heated in boiling water at 98 plus or minus 1 degree C and applied for 10 s

Both the ointment and the gel containing curcumin and ampicillin solid lipid nanoparticles significantly increased the rate of burn wound healing relative to placebo bases and saline, with only very slight dermal irritation and no corrosive response in rabbits.

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Effect of curcumin on acute spinal cord injury in mice via inhibition of inflammation and TAK1 pathway.

Model: Acute traumatic spinal cord injury induced by the Allen weight-drop method

Curcumin concentration-dependently inhibited injury-induced TNF-alpha, IL-1beta, IL-6 and nitric oxide production, reduced phosphorylation of TAK1, MKK6 and p38 MAPK, down-regulated IkappaB and IKK, reduced GFAP expression at the medium and high doses, and significantly improved hindlimb functional…

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Curcumin attenuates lipopolysaccharide/d-galactosamine-induced acute liver injury by activating Nrf2 nuclear translocation and inhibiting NF-kB activation.

Model: Acute liver injury induced by intraperitoneal injection of 8 micrograms lipopolysaccharide with 800 mg/kg d-galactosamine in sterile 0.9 per cent sodium chloride

Curcumin pretreatment reduced hepatic pathological damage, serum transaminases, malondialdehyde and tumour necrosis factor alpha, inhibited nuclear factor kappa B activation and dose-dependently upregulated nuclear Nrf2 and its antioxidant target genes.

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A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors.

Model: Image-guided focal irradiation of the jejunum using a surgically implanted radiopaque fiducial marker, cone-beam CT targeting and the Small Animal Radiation Research Platform, delivering a 5 mm focal intestinal radiation field

Focal 5 mm intestinal irradiation produced acute reversible damage confined to the marked area, without weight loss or lethality, but with fibrosis and collagen deposition indicating chronic damage at 4 months. Curcumin-treated mice showed significant decreases in both local and systemic inflammato…

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Protective effects of curcumin against mercury-induced hepatic injuries in rats, involvement of oxidative stress antagonism, and Nrf2-ARE pathway activation.

Model: Mercuric chloride induced acute hepatotoxicity

Mercuric chloride caused dose-dependent hepatotoxicity with raised oxidative stress and apoptosis markers and activation of Nrf2 signalling. Curcumin pretreatment markedly prevented mercuric chloride induced hepatic oxidative stress, attributed to radical scavenging or induction of the Nrf2 antioxi…

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CISD2 serves a novel role as a suppressor of nitric oxide signalling and curcumin increases CISD2 expression in spinal cord injuries.

Model: Acute traumatic spinal cord injury in rats, with lipopolysaccharide-challenged neural cell culture as an in vitro inflammation model

Spinal cord injury reduced CISD2 mRNA and protein expression in vivo and curcumin treatment upregulated CISD2-positive cells. Curcumin at 1 micromolar attenuated LPS-induced CISD2 downregulation in vitro, and CISD2 knockdown produced a pronounced increase in iNOS with decreased BCL2.

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Curcumin improves the recovery of motor function and reduces spinal cord edema in a rat acute spinal cord injury model by inhibiting the JAK/STAT signaling pathway.

Model: Acute spinal cord injury induced by a falling weight

Curcumin moderately improved locomotor recovery and reduced haemorrhage, oedema and neutrophil infiltration, with reduced aquaporin-4 and GFAP expression and suppressed JAK/STAT activation.

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Curcumin attenuates liver warm ischemia and reperfusion-induced combined restrictive and obstructive lung disease by reducing matrix metalloprotease 9 activity.

Model: Hepatic warm ischaemia by 30 min occlusion of the hepatic artery and portal vein followed by 48 h reperfusion, with secondary lung injury

Curcumin improved all measured lung function indices and reduced serum alanine transaminase, lung tumour necrosis factor alpha and matrix metalloproteinase 9 activity.

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Curcumin treatment attenuates pain and enhances functional recovery after incision.

Model: Hindpaw plantar incision model of postoperative pain

Curcumin reduced mechanical and heat sensitisation and hindpaw swelling after incision, attenuated hyperalgesic priming, abolished evidence of spontaneous pain in the conditioned place preference paradigm at 48 hours and normalised most gait indices, without reducing pronociceptive cytokines but wi…

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Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-kappaB signaling pathway in experimental traumatic brain injury.

Model: Weight-drop contusion traumatic brain injury; microglia and neuron co-culture with lipopolysaccharide stimulation in vitro

TLR4 protein peaked at 24 h after injury and TLR4 knockout mice showed less functional impairment, oedema and cytokine release. Curcumin at 100 mg/kg reduced TLR4-positive microglia and macrophages, inflammatory mediator release and neuronal apoptosis, and lowered TLR4, MyD88 and NF-kappaB levels,…

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The neuroprotective effect of treatment with curcumin in acute spinal cord injury: laboratory investigation.

Model: Clip compression spinal cord injury: laminectomy at T9 and application of a modified aneurysm clip with 30 g closing force vertically onto the exposed cord for 2 minutes, under intraperitoneal xylazine 10 mg/kg and ketamine 60 mg/kg anaesthesia

Curcumin improved every endpoint: BBB scores were higher than vehicle from day 7 (P<0.05), cavitation volume fell from 2.21 (SD 0.31) to 1.18 (SD 0.20) mm3 (P=0.039) with more spared tissue at the epicentre (P=0.006), ED-1 macrophage activity was 27.1% lower at 2 weeks (P=0.001), plasma superoxide…

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Curcumin treatment protects against renal ischemia and reperfusion injury-induced cardiac dysfunction and myocardial injury.

Model: Renal ischaemia and reperfusion injury induced by bilateral occlusion of the renal pedicles for 45 minutes followed by 3 hours of reperfusion, with assessment of remote cardiac injury

Renal ischaemia-reperfusion reduced stroke volume, ejection fraction and systolic pressure and raised CK-MB, cardiac troponin I, creatinine and blood urea nitrogen. Curcumin pre-treatment ameliorated ESPVR, improved cardiac contractility and attenuated both myocardial and renal injury, attributed t…

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Chronic curcumin treatment normalizes depression-like behaviors in mice with mononeuropathy: involvement of supraspinal serotonergic system and GABAA receptor.

Model: Chronic constriction injury (CCI) of the sciatic nerve producing mononeuropathy

Chronic oral curcumin corrected both the thermal hyperalgesia and the prolonged immobility (depressive-like behaviour) of neuropathic mice. The antidepressant-like action was abolished by brain serotonin depletion but not noradrenaline depletion, blocked by repeated WAY-100635 and greatly attenuate…

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Localized leptin release may be an important mechanism of curcumin action after acute ischemic injuries.

Model: Intestinal ischaemia/reperfusion injury

Curcumin significantly improved survival and reduced intestinal pathological injury, water content, malondialdehyde, interleukin-1beta and interleukin-6, while increasing superoxide dismutase. Reduced leptin and Ob-Rb were restored and ERK1/2 and p38 MAPK signalling normalised, with the effect reve…

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The effect of curcumin on lung injuries in a rat model induced by aspirating gastrointestinal decontamination agents.

Model: Aspiration of polyethylene glycol solution or activated charcoal causing acute lung injury

Curcumin attenuated pulmonary inflammation and alveolar damage, lowered serum malondialdehyde and surfactant protein D, and inhibited TNF-alpha and IL-1beta expression.

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Protective effect of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion.

Model: intestinal ischaemia/reperfusion, 1 h superior mesenteric artery ligation followed by 1 h reperfusion, causing acute lung injury

Curcumin lowered lung malondialdehyde, raised superoxide dismutase and glutathione peroxidase activity, reduced inducible nitric oxide synthase and increased surfactant protein D, and attenuated oedema, haemorrhage and inflammatory infiltration.

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Curcumin improves the survival rate after a massive hepatectomy in rats.

Model: Ninety per cent (massive) hepatectomy causing acute liver failure

Six of 13 curcumin-pretreated rats survived, whereas all 13 vehicle-pretreated rats died within 2 days of massive hepatectomy. Lobular architecture remained relatively preserved without necrosis in curcumin-treated animals, and haem oxygenase-1 protein was elevated preoperatively and remained high…

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Accelerated and scarless wound repair by a multicomponent hydrogel through simultaneous activation of multiple pathways.

Model: Full-thickness acute skin wound

A single application of the curcumin and cerium oxide nanoparticle-loaded hydrogel achieved 78% wound healing efficacy at 7 days with negligible scarring, exceeding dressings containing either component alone. Healing was accompanied by greater cell proliferation, collagen content, wound maturity,…

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Protective effect of curcumin nanoparticles against cardiotoxicity induced by doxorubicin in rat.

Model: Acute doxorubicin-induced cardiotoxicity (single acute dose of doxorubicin 20 mg/kg)

Curcumin nanoparticle pretreatment prevented doxorubicin-induced tachycardia and electrocardiographic changes and normalised oxidative stress, enzyme activity and monoamine markers.

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Electroacupuncture and Curcumin Promote Oxidative Balance and Motor Function Recovery in Rats Following Traumatic Spinal Cord Injury.

Model: Traumatic spinal cord injury

Electroacupuncture and curcumin, alone or combined, lowered oxidative stress markers, improved motor recovery and increased preserved spinal cord tissue.

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Effect of curcumin on lipid peroxidation, early ultrastructural findings and neurological recovery after experimental spinal cord contusion injury in rats.

Model: Spinal cord contusion by 50 g/cm weight drop

Curcumin significantly decreased lipid peroxidation in the first 24 h and was more effective than dimethyl sulfoxide or methylprednisolone for this endpoint. Neurological scores did not differ between treated and control groups and dimethyl sulfoxide was better at minimising ultrastructural change.

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Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice

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Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4?

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Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury

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Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma

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Curcumin treatment enhances the repair and regeneration of wounds in mice exposed to hemibody gamma-irradiation

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Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer

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Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines

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Radioprotective action of curcumin extracted from Curcuma longa LINN: inhibitory effect on formation of urinary 8-hydroxy-2'-deoxyguanosine, tumorigenesis, but not mortality, induced by gamma-ray irradiation

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