Spinal cord transplants permit the growth of serotonergic axons across the site of neonatal spinal cord transection.
RatSpinal cord injuryComplete transectionInbred strain (not further specified)Intraspinal transplantation into the lesion siteAt the time of neonatal transection
Model: Mid-thoracic spinal cord transection on the day of birth
Transection abolished caudal 5-HT immunoreactivity by 5 days, with no return after acute or 6-month survival. With a fetal transplant, 5-HT axons were found throughout the graft and in host white and grey matter caudal to the lesion as far as lower lumbar levels, although reinnervation density was…
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