Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Spinal cord injury
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 3
3 studies reported at therapy level; 3 evidence entries itemised.
RatSpinal cord injuryHemisection / partialInbred strain not specifiedFemaleTransplantation into the hemisection cavity2-7 weeks after injury (chronic lesion)
Model: Lumbar spinal cord hemisection cavity, allowed to become chronic for 2-7 weeks before grafting
Grafts placed into chronic hemisection cavities showed 90% long-term survival and good differentiation. Despite a dense astrocytic scar, foci of confluent host-graft neuropil formed, mainly at host grey matter interfaces. Tract tracing suggested axonal projections into grafts from adjacent host neu…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
RatSpinal cord injuryHemisection / partialIntraspinal transplantation into the lesion cavityAcute and chronic (delayed) transplantation
Model: Hemisection and contusion lesions of the adult rat spinal cord, acute and chronic
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.25. Machine-extracted fields require source verification.
RatSpinal cord injuryComplete transectionInbred strain (not further specified)Intraspinal transplantation into the lesion siteAt the time of neonatal transection
Model: Mid-thoracic spinal cord transection on the day of birth
Transection abolished caudal 5-HT immunoreactivity by 5 days, with no return after acute or 6-month survival. With a fetal transplant, 5-HT axons were found throughout the graft and in host white and grey matter caudal to the lesion as far as lower lumbar levels, although reinnervation density was…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
