Efficacy of two leukotriene antagonists in rat traumatic shock.
RatOtherInbred strain (not further specified)Male
Model: Noble-Collip drum traumatic shock in pentobarbital-anaesthetised rats
Trauma produced a survival time of 128 +/- 16 min and a four-fold rise in plasma myocardial depressant factor. Both compounds significantly attenuated myocardial depressant factor accumulation (24 +/- 3 and 29 +/- 3 U/ml versus 57 +/- 5 U/ml in the vehicle group, p less than 0.01) and improved surv…
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