THERAPY DOSSIER · th-2bb918062a04

CGP 33304 and CGP 35949

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 3613754 ↗1987Reported benefit

Efficacy of two leukotriene antagonists in rat traumatic shock.

RatOtherInbred strain (not further specified)Male

Model: Noble-Collip drum traumatic shock in pentobarbital-anaesthetised rats

Trauma produced a survival time of 128 +/- 16 min and a four-fold rise in plasma myocardial depressant factor. Both compounds significantly attenuated myocardial depressant factor accumulation (24 +/- 3 and 29 +/- 3 U/ml versus 57 +/- 5 U/ml in the vehicle group, p less than 0.01) and improved surv…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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