Individual and synergistic protective properties of Salvia officinalis flowers decoction extract and sulfasalazine against ethanol-induced gastric and small bowel injuries
RatChemical/toxinWistarMalen = 6 groups of 8 rats each (n=48 total)Oral (gavage)SOFDE 100 or 200 mg/kg b.w. p.o.; sulfasalazine 100 mg/kg b…Pretreatment for 15 days, last dose 60 min before ethanol challenge (18 h fasti…
Model: Ethanol (4 g/kg, oral)-induced gastric and duodenal (peptic) ulcer
SOFDE alone and combined with sulfasalazine (MIX) significantly protected against ethanol-induced gastric and duodenal macroscopic and histological injury, reduced oxidative stress markers (MDA, H2O2), restored antioxidant enzyme activities and non-enzymatic antioxidants, normalised free iron/calci…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.