THERAPY DOSSIER · th-11e9da3ef14d

Salvia officinalis flowers decoction extract (SOFDE) alone or combined with sulfasalazine (MIX)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04565912 ↗NAunknown

Efficacy of Sage Extract or Chlorhexidine Mouthwashes on Streptococcus Mutans Pathogenicity in High Caries Risk Patients

Streptococcus Mutans

Enrolment: 37 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 35517119 ↗2020Reported benefit

Individual and synergistic protective properties of Salvia officinalis flowers decoction extract and sulfasalazine against ethanol-induced gastric and small bowel injuries

RatChemical/toxinWistarMalen = 6 groups of 8 rats each (n=48 total)Oral (gavage)SOFDE 100 or 200 mg/kg b.w. p.o.; sulfasalazine 100 mg/kg b…Pretreatment for 15 days, last dose 60 min before ethanol challenge (18 h fasti…

Model: Ethanol (4 g/kg, oral)-induced gastric and duodenal (peptic) ulcer

SOFDE alone and combined with sulfasalazine (MIX) significantly protected against ethanol-induced gastric and duodenal macroscopic and histological injury, reduced oxidative stress markers (MDA, H2O2), restored antioxidant enzyme activities and non-enzymatic antioxidants, normalised free iron/calci…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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