Bile loss in the acute intestinal radiation syndrome in rats.
RatRadiationSurgical (bile duct ligation, choledochostomy); intraperitoneal and duodenal injection of fluid and electrolytes; intraluminal cholestyramineCholestyramine given after irradiation; timing of bile duct ligation and choled…
Model: Whole-body irradiation (137Cs gamma rays, fission neutrons, or cyclotron-produced neutrons) at doses producing acute intestinal death, including 15.4 Gy
Bile duct ligation significantly prolonged survival and delayed diarrhoea onset, and intraperitoneal fluid and electrolytes gave a comparable increase in survival that was further extended, up to 9 days, by adding antibiotics, with mucosal regeneration seen in long-term survivors. Choledochostomy a…
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