THERAPY DOSSIER · th-f3b77cb08558

Bile duct ligation, choledochostomy, intraperitoneal or duodenal fluid and electrolyte replacement, antibiotics, and intraluminal cholestyramine

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 3544009 ↗1987Mixed findings

Bile loss in the acute intestinal radiation syndrome in rats.

RatRadiationSurgical (bile duct ligation, choledochostomy); intraperitoneal and duodenal injection of fluid and electrolytes; intraluminal cholestyramineCholestyramine given after irradiation; timing of bile duct ligation and choled…

Model: Whole-body irradiation (137Cs gamma rays, fission neutrons, or cyclotron-produced neutrons) at doses producing acute intestinal death, including 15.4 Gy

Bile duct ligation significantly prolonged survival and delayed diarrhoea onset, and intraperitoneal fluid and electrolytes gave a comparable increase in survival that was further extended, up to 9 days, by adding antibiotics, with mucosal regeneration seen in long-term survivors. Choledochostomy a…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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