Morphometric assessment of drug effects in experimental spinal cord injury.
RatSpinal cord injuryCompressionmaleDescribed only as large doses of methylprednisolone sodium…
Model: Epidural compression of the T-11 spinal cord segment with a surgical clip
Methylprednisolone significantly reduced axonal degeneration at day 7, with a mean degeneration index difference of 6 (p less than 0.05). Leupeptin preserved axons at days 7, 10 and 14, with degeneration index differences of 16 (p less than 0.001), 12 (p less than 0.001) and 13 (p less than 0.01) r…
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