Comprehensive infusion guidance for infusion-associated reactions in RRMS patients treated with LEMTRADA (includes methylprednisolone)
Relapsing-remitting Multiple Sclerosis
Enrolment: 58 · Results not recorded
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Drug · Glucocorticoid receptor agonist (ChEMBL mechanism on active parent CHEMBL650); prodrug, parenteral. Leupeptin and bestatin (protease/aminopeptidase inhibitors) not separately resolved.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Relapsing-remitting Multiple Sclerosis
Enrolment: 58 · Results not recorded
Breast Neoplasms · Mastectomy
Enrolment: 40 · Results not recorded
Multiple Sclerosis Relapsing Remitting
Enrolment: 80 · Results not recorded
Sudden Deafness · Sensorineural Hearing Loss
Enrolment: 30 · Results not recorded
Myasthenia Gravis
Enrolment: 9 · Results not recorded
Leukemia · Lymphoma · Myelodysplastic Syndromes · Graft Versus Host Disease
Enrolment not recorded · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Epidural compression of the T-11 spinal cord segment with a surgical clip
Methylprednisolone significantly reduced axonal degeneration at day 7, with a mean degeneration index difference of 6 (p less than 0.05). Leupeptin preserved axons at days 7, 10 and 14, with degeneration index differences of 16 (p less than 0.001), 12 (p less than 0.001) and 13 (p less than 0.01) r…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Severe T9 contusion spinal cord injury using the New York University weight-drop device, 10 g rod from 50 mm height after T9 laminectomy
Methylprednisolone blocked the injury-induced rise in AQP4, increased Evans blue extravasation by about 80% and raised spinal water content, worsening oedema without any motor improvement at 24 h.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.